Ian Mackay, PhD

Research Interests:
Quantitative genetics and plant breeding. Human genetics.

Publications:
Taylor, J.C., Gough, S.C., Hunt, P.J., Brix, T.H., Chatterjee, K., Connell, J.M., Franklyn, J.A., Hegedus, L., Robinson, B.G., Wiersinga, B.G., Wass, J.A.H., Zabaneh, D., Mackay, I., Weetman, J.A.H. (2005) A Genome-wide Screen in 1119 Relative Pairs with Autoimmune Thyroid Disease. The Journal of Clinical Endocrinology & Metabolism. [Epub ahead of print]

Dechairo, B.M., Zabaneh, D., Collins, J.,Brand O., Dawson, G.J., Green, A.P. Mackay. I., Franklyn, A., Connell JM., Wass, A.H., Wiersinga, M., Hegedus, L., Brix, T., Robinson, B.G., Hunt, P.J., Weetman, A.P., Carey, A.H. Gough, S.C. (2005) Association of the TSHR gene with Graves' disease: the first disease specific locus. Eur J Hum Genet. 13, 1223-1230

Reid, D.M., Mackay, I., Wilkinson, S., Miller, C., Schuette, D.G., Compston, J., Cooper, C., Duncan, E., Galwey, N., Keen, R., Langdahl, B., McLellan,A., Pols, H., Uitterlinden, O’Riordan, J., Wass, J.A.H., Ralston, S.H., Bennett, S.T. (2005) Cross-calibration of Dual Energy X-ray densitometers for a large, multi-centre genetic study of osteoporosis. Osteoporosis Int. 17, 125-132

Treloar, S.A., Wick,s J., Nyholt, D.R., Montgomery, G.W., Bahlo, M,. Smith, V., Dawson, G., Mackay, I.J., Weeks, D.E., Bennett, S.T., Carey, A., Ewen-White, K.R., Duffy, D.L., O'Connor, D.T., Barlow, D.H., Martin, N.G., Kennedy, S.H. (2005) Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26. Am J Hum Genet. Jul 21;77, 365-276

Lench, N., Iles, M.M., Mackay, I., Patel, R., Sagoo, G.S., Ward, S.J. Dechairo, B., Olavesen, M., Carey, A., Duff, G.W., Cork, M.J., Tazi-Ahnini, R. (2005) Single point haplotype scores telomeric to HLA-C give a high susceptibility MHC haplotype for psoriasis in a Caucasian Population. Journal of Investigative Dermatology. 124, 545-52.

Pardo, M., MacKay, I., Oostra, B., van Duijn, C.M., Aulchenko, Y.S. (2005) The effect of genetic drift in a young genetically isolated population. Annals of Human Genetics. 69, 288-295

Pettipher, R., Mangion J., Hunter, M.G., Mackay I. (2005) Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies. Current Opinion in Pharmacology 5, 412–417

Ralston, S.H., Galwey, N., MacKay, I., Albagha1,O.M.E., Cardon L., Compston, J.E., Cooper, C., Duncan, E., Keen, R., Langdahl, B., McLellan, A., O’Riordan, J., Pols, H.A., Reid, D.M., Uitterlinden, A.G., Wass, J., Bennett, S.T. (2005) Loci for regulation of bone mineral density and fracture in men and women identified by a large whole-genome linkage scan: the FAMOS study. Human Molecular Genetics. 14, 943-951

Aulchenko, Y.S, Heutink P, Mackay I, Bertoli-Avella AM, Pullen J, Vaessen N, Rademaker TA, Sandkuijl LA, Cardon L, Oostra B, Duijn CM. (2004). Linkage disequilibrium in young genetically isolated Dutch population. Eur J Hum Genet. 12:527-534.

Aulchenko, Y.S., Axenovich, T. I, Mackay I, van Duijn, C.M. miLD and booLD programs for calculation and analysis of adjusted linkage disequilibrium. (2003) Annals of Human Genetics. 67: 372-375.

Martin, J.M.R., Mackay, I.J. and Rawlings, C.J. (2003). Pedstrip: extracting a maximal subset of available, unrelated individuals from a pedigree. Bioinformatics 19 291-292.

van Heel D.A., Dechairo B.M., Dawson G., McGovern D.P., Negoro K., Carey A.H., Cardon L.R., Mackay I., Jewell D.P., Lench N.J. (2003). The IBD6 Crohn’s disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. Human Molecular Genetics 15, 2569-2575.

Whittaker J.C., Harbord R.M., Boxall N., Mackay I., Dawson G., Sibly R.M. (2003). Likelihood-based estimation of microsatellite mutation rates. Genetics. 164. 781-787.

Zabaneh, D., and Mackay, I.J., (2003). Genome-wide linkage scan on estimated breeding values for a quantitative trait. BMC Genet. 4 Suppl 1:S61.

Berry V., Francis P., Reddy M.A., Collyer D., Vithana E., MacKay I., Dawson G., Carey A.H., Moore A., Bhattacharya S.S., Quinlan R.A. (2001) Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. Am J Hum Genet. 69:1141-1145.

Dechairo, B., Dimon, C., van Heel, D., Mackay, I., Edwards, M., Scambler, P., Jewell, D., Cardon, L., Lench. N. and Carey. A. (2001) Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3). Eur J Hum Genet. 9: 627-633.

Cardon L.R., Garner C., Bennett S.T., Mackay I.J., Edwards R.M., Cornish J., Hegde M., Murray M.A., Reid I.R., Cundy T. (2000) Evidence for a major gene for bone mineral density in idiopathic osteoporotic families. J Bone Miner Res. 15: 1132-1137.

Foster, R., Pooni, H.S. and Mackay, I.J. (2000). The potential of selected Linum usitatissimum crosses for producing recombinant inbred lines with dual-purpose characteristics. Journal of Agricultural Science, Cambridge. 134: 399-404.

Mackay, I.J. and Caligari, P.D.S. (2000) Methods of increasing short term response to full-sib family recurrent selection in small populations. Euphytica. 113: 53-64.

Mackay, I..J. and Caligari, P.D.S. (2000) Efficiencies of F2 and Backcross Generations for Bulked Segregant Analysis Using Dominant Markers. Crop Science. 40 :626-630.

Mackay, I.J., Cardon, L., the FAMOS Study Collaborators and Bennett, S.T. (2000) FAMOS: towards genetic dissection of osteoporosis. Calcified Tissue International. 67: 499.

Mackay, I.J. and Caligari, P.D.S. (1999) Major errors in data and their effect on response to selection in plants. Crop Science. 39: 697-702.

Mackay, I.J., and Caligari, P.D.S., Gibson, J.P. (1999). Accelerated Recurrent Selection. Euphytica 105: 43-51.

Mackay, I.J., Gibson, J.P. and Caligari, P.D.S. (1999) The genetics of selfing with concurrent backcrossing in breeding hybrid sugar beet (Beta vulgaris altissima L.). Theoretical and Applied Genetics. 98: 1156-1162.

Mackay, I.J. (1998). From cucumber sun-beams onward. Review of ‘Quantitative and ecological aspects of plant breeding’ by J. Hill, H.C. Becker and P.M.A. Tigerstedt. Trends in Plant Science 28, 157.

Foster, R., Pooni, H.S. and Mackay, I.J. (1998). Quantitative evaluation of Linum usitatissimum crosses for dual purpose traits. Journal of Agricultural Science, Cambridge. 131: 285-292.

Foster, R., Pooni, H.S. and Mackay, I.J. (1998). The impact of water deprivation on the performance of Linum usitatissimum cultivars. Journal of Genetics and Breeding. 52: 63-71.

Foster, R., Pooni, H.S. and Mackay, I.J. (1997). Quantitative evaluation of Linum usitatissimum varieties for dual purpose traits. Journal of Agricultural Science, Cambridge. 129: 179-185.

Zhao, B., Mackay, I.J., Caligari, P.D.S. and Mead, R. (1997). The efficiency of between and within full-sib family selection in a recurrent selection programme in sugar beet (Beta vulgaris L.) Euphytica 95, 355-359.

Mackay, I.J. (1996). Selection methods in plant breeding by I. Bos and P Caligari 1995. Book review. Heredity 77, 336-340.

Zhao, B., Mackay, I.J., Mead, R. and Caligari, P.D.S. (1996). The design and analysis of breeders’ trials of sugar beet (Beta vulgaris) using two dimensional blocking structure. Annals of Applied Biology 132, 497-506.

Mackay, I.J. and Gibson, J.P. (1993). The effect of gametic-phase disequilibrium on the prediction of response to recurrent selection in plants. Theoretical and Applied Genetics 87, 152-160.

Mackay, I.J. and Patton, F. (1993). A plain man’s guide to sugar beet breeding. British Sugar Beet Review 61, 57-61.

Mackay, I.J. (1992). Fundamentals of plant breeding by H. Kuckuck, G. Kobabe and G. Wenzel 1991. Book review. Heredity 69, 199-200.

Cornish, M.A., Smith, M.C. and Mackay, I.J. (1990). An evaluation of single plant randomised field trials of sugar beet (Beta vulgaris L.). Euphytica 45, 1-7.

Smith M.C., Cornish, M.A and Mackay, I.J. (1990). An analysis of genetic variation in sugar beet (Beta vulgaris L.) using an augmented biparental (ABIP) mating design. Annals of Applied Biology 116, 583-590.

Smith, M.C., Mackay, I.J. and Cornish, M.A. (1990). A diallel analysis of germination in sugar beet (Beta vulgaris L.). Seed Science and Technology 18, 43-50.

Gale, J.S. and Mackay, I.J. (1979). Evolution of dominance. Nature 280, 613.

Gale, J.S. and Mackay, I.J. (1979). Natural selection in Papaver dubium. Heredity 43, 454.